Appears safe based on current evidence
Safety assessments compiled from FDA, EFSA, FSA, and 7 other regulatory agencies. This information is for educational purposes — consult a healthcare professional for dietary advice.
Epsilon-Polylysine
Last reviewed: April 2026 · Data sourced from WHO JECFA, FDA, EFSA, and 7 other regulatory agencies
At a Glance
Quick Answer
Epsilon-Polylysine is rated "Appears Safe" according to current evidence. It is approved in the EU and approved in the US. This additive is banned or not approved in at least one major market.
On This Page
What is Epsilon-Polylysine?
Natural antimicrobial peptide from Streptomyces. Used in Japan since 1989. GRAS in US since 2004. Not approved in EU. Effective against broad range of microorganisms
Epsilon-Polylysine is classified as a Preservative additive. It is banned or restricted in at least one major country.
Regulatory Status by Country
🇺🇸 United StatesUS
ApprovedNatural antimicrobial peptide from Streptomyces. Used in Japan since 1989. GRAS in US since 2004. Not approved in EU. Effective against broad range of microorganisms
🇪🇺 European UnionEU
NOT APPROVEDNatural antimicrobial peptide from Streptomyces. Used in Japan since 1989. GRAS in US since 2004. Not approved in EU. Effective against broad range of microorganisms
🇬🇧 United KingdomUK
Same as EUFollows EU regulations
🇯🇵 Japan
Check MHLW🇨🇦 CanadaCA
ApprovedGenerally aligned with US FDA. Regulated by Health Canada.
🇦🇺 Australia/NZAU/NZ
Likely restrictedMay follow EU restrictions. Check FSANZ Schedule 15.
🇮🇳 India
May be restrictedCheck FSSAI regulations. India follows Codex Alimentarius guidelines.
🇰🇷 South KoreaKR
May be restrictedCheck MFDS (Ministry of Food and Drug Safety).
🇧🇷 Brazil
ApprovedGenerally aligned with Codex/US standards. Regulated by ANVISA.
🇨🇳 China
May be restrictedChina has independent standards. Check GB 2760.
Note: Canada, Australia/NZ, India, South Korea, Brazil, and China statuses are inferred from international regulatory patterns. Always verify with the relevant national authority.
This additive is banned or not approved in at least one country
Regulatory agencies in different countries may reach different conclusions about the same ingredient based on their assessment criteria, acceptable risk levels, and available evidence. Always check the latest regulations in your region.
Expert Analysis
Epsilon-Polylysine is classified as a preservative in the food additive regulatory framework. Current scientific evidence supports its safety when consumed within established limits. Notably, regulatory agencies disagree on this additive — it is approved in the EU but approved in the US. This regulatory divergence reflects different risk assessment philosophies between jurisdictions. As with all food additives, moderation is key. Consult healthcare professionals for personalized dietary advice.
Is Epsilon-Polylysine safe?
Epsilon-Polylysine has a safety rating of "Appears Safe". Appears safe based on current evidence
Is Epsilon-Polylysine vegan?
Epsilon-Polylysine is generally considered vegan-friendly, though sourcing may vary.
Is Epsilon-Polylysine banned in Europe?
No, Epsilon-Polylysine is NOT APPROVED in the EU.
What is Epsilon-Polylysine made from?
Natural antimicrobial peptide from Streptomyces. Used in Japan since 1989. GRAS in US since 2004. Not approved in EU. Effective against broad range of microorganisms
Weekly Ingredient Alert
Get weekly updates on food additive news, regulatory changes, and safety alerts.
Recommended Reading
Frequently Asked Questions
Is Epsilon-Polylysine safe?
Is Epsilon-Polylysine banned in any country?
What is Epsilon-Polylysine used for?
Sources & References
Regulatory data for Epsilon-Polylysine is sourced from the following agencies:
- FDA: Substances Added to Food (formerly EAFUS)
- EFSA: Food Additives Database
- FSA: Approved Additives and E Numbers
- MHLW: Standards for Use of Food Additives
- Health Canada: Lists of Permitted Food Additives
- FSANZ: Food Additives
- FSSAI: Food Safety and Standards
- MFDS: Food Additives Standards
- ANVISA: Food Additives Legislation
- GB 2760: National Food Safety Standard
- WHO JECFA: International Safety Evaluations
- CSPI: Chemical Cuisine — Food Additive Safety Ratings
Often Found Together
Other additives with the same safety rating from different categories
Related Searches
People also ask:
Want Additive-Free Food?
Explore organic food delivery services that prioritize clean ingredients.
Explore Clean Food Options →