Appears safe based on current evidence
Safety assessments compiled from FDA, EFSA, FSA, and 7 other regulatory agencies. This information is for educational purposes — consult a healthcare professional for dietary advice.
Gamma-Cyclodextrin
Last reviewed: April 2026 · Data sourced from WHO JECFA, FDA, EFSA, and 7 other regulatory agencies
At a Glance
Quick Answer
Gamma-Cyclodextrin (E458) is rated "Appears Safe" according to current evidence. It is approved in the EU and approved in the US. This additive is currently approved in all four major markets (US, EU, UK, Japan).
On This Page
What is Gamma-Cyclodextrin?
Cyclic sugar. Encapsulation agent
Gamma-Cyclodextrin is classified as a Thickener additive. It is currently approved in all major regulatory markets.
Regulatory Status by Country
🇺🇸 United StatesUS
Check FDA database🇪🇺 European UnionEU
ApprovedCyclic sugar. Encapsulation agent
🇬🇧 United KingdomUK
Same as EU pre-BrexitUK retained EU food additive regulations post-Brexit with some modifications
🇯🇵 Japan
Check MHLW database🇨🇦 CanadaCA
Check Health CanadaVerify with Health Canada's permitted food additives list.
🇦🇺 Australia/NZAU/NZ
ApprovedGenerally aligned with EU standards. Regulated by FSANZ.
🇮🇳 India
Check FSSAIVerify with Food Safety and Standards Authority of India.
🇰🇷 South KoreaKR
Check MFDSVerify with South Korea's Ministry of Food and Drug Safety.
🇧🇷 Brazil
Check ANVISAVerify with Brazil's ANVISA.
🇨🇳 China
Check GB 2760Verify with China's GB 2760 National Food Safety Standard.
Note: Canada, Australia/NZ, India, South Korea, Brazil, and China statuses are inferred from international regulatory patterns. Always verify with the relevant national authority.
Expert Analysis
Gamma-Cyclodextrin is classified as a thickener in the food additive regulatory framework. Current scientific evidence supports its safety when consumed within established limits. This additive is approved across multiple major regulatory markets worldwide, suggesting broad scientific consensus on its safety profile. As with all food additives, moderation is key. Consult healthcare professionals for personalized dietary advice.
Is Gamma-Cyclodextrin safe?
Gamma-Cyclodextrin has a safety rating of "Appears Safe". Appears safe based on current evidence
Is Gamma-Cyclodextrin vegan?
Gamma-Cyclodextrin is generally considered vegan-friendly, though sourcing may vary.
Is Gamma-Cyclodextrin banned in Europe?
No, Gamma-Cyclodextrin is Approved in the EU.
What is Gamma-Cyclodextrin made from?
Cyclic sugar. Encapsulation agent
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Recommended Reading
Frequently Asked Questions
Is Gamma-Cyclodextrin safe?
Is Gamma-Cyclodextrin banned in any country?
What is Gamma-Cyclodextrin used for?
Sources & References
Regulatory data for Gamma-Cyclodextrin is sourced from the following agencies:
- FDA: Substances Added to Food (formerly EAFUS)
- EFSA: Food Additives Database
- FSA: Approved Additives and E Numbers
- MHLW: Standards for Use of Food Additives
- Health Canada: Lists of Permitted Food Additives
- FSANZ: Food Additives
- FSSAI: Food Safety and Standards
- MFDS: Food Additives Standards
- ANVISA: Food Additives Legislation
- GB 2760: National Food Safety Standard
- WHO JECFA: International Safety Evaluations
- CSPI: Chemical Cuisine — Food Additive Safety Ratings
Often Found Together
Other additives with the same safety rating from different categories
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